H‑Wave MOA Further Identified in Placebo Controlled Study
H‑Wave effects on blood flow and angiogenesis
The Wake Forest University Department of Orthopedics has had their research regarding H‑Wave published in the Journal of Surgical Orthopaedic Advances. 
H‑Wave increased limb blood flow upon application by 200%. After repetitive application over three weeks limb blood flow upon application was increased by 247% revealing an increased vascular reserve. Angiogenesis was statistically confirmed by counting and averaging the number of new blood vessel. In contrast significant angiogenesis was not observed in the Sham conditioned groups.
Angiogenesis is a physiological process involving the growth of new blood vessels from pre-existing vessels. Therapeutic angiogenesis is the application of specific compounds and or devices which induce the creation of new blood vessels in the body in order to combat disease. The absence of blood vessels in a repairing or otherwise metabolically active tissue may retard repair or some other function. Tissue regeneration involves the formation of new blood vessels regulated by angiogenic factors.
This study provided further insights into the unique mechanisms of H‑Wave electrical stimulation and its clinical effectiveness.
Journal of Surgical Orthopaedic Advances. Volume 20, Number 4, Winter 2011. 255-259.